Tests revealed that the molecule matrix metalloproteinase 2 might play a crucial role within the repair of arteries. The wound-healing immune system cells discharge Mmp2, which reduces the matrix, or glue, keeping cells together, enabling room for arteries to become rebuilt. When Mmp2 was clogged, there is a large reduction in the true amount of vessels which were repaired. Further research is required to uncover extra molecules and genes mixed up in repair procedures and identify methods to increase the span of recovery following mind injury..Kousteni. The first clues to another hormone came this year 2010, when Dr. Kousteni found that disabling a gene known as FOXO1 in mouse osteoblasts triggered the mice to consume much less and improved their blood sugar stability. ‘Since osteocalcin will not regulate urge for food, we knew a second bone tissue hormone needed to be involved in this technique,’ stated Dr. Kousteni. In today’s study, the CUMC researchers demonstrated that FOXO1-deficient osteoblasts exhibit unusually high levels of a protein called lipocalin 2.